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  1. Home/
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  4. Buffalo Bills vs Los Angeles Chargers

Buffalo Bills vs Los Angeles ChargersNFL Picks, Prediction & Odds • Sep 27 • 01:00 PM

NFL

Sunday, September 27, 2026

Buffalo Bills logo

Buffalo Bills

0-0
Sep 27 • 01:00 PM
Starting Now
Los Angeles Chargers logo

Los Angeles Chargers

1Picks

Experts Betting This Game

1 expert has a pick on Buffalo Bills vs Los Angeles Chargers

View Expert Picks
Oskeim Sports

Oskeim Sports

70% Win Rate
Pick on this game
Premium pick +100Unlock
Oskeim Sports

Oskeim Sports

70% Win Rate
Pick on this game
Premium pick +100Unlock

Our Prediction

Buffalo Bills logoBuffalo Bills75%
25%Los Angeles ChargersLos Angeles Chargers logo
Buffalo Bills logo
Buffalo Bills
VS
Los Angeles Chargers logo
Los Angeles Chargers
Confidence
Medium

We predict Buffalo Bills

Key Factors

Betting Odds

Betting odds imply a 75% chance for Buffalo Bills

1

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Buffalo Bills logoBuffalo Bills
Los Angeles ChargersLos Angeles Chargers logo
Spread
-7.00
-115
7.00
-108
Moneyline
-370
FAV
+285
Total (O/U 50.00)
Over
-114
Under
-108

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Frequently asked questions

Who is favored to win Buffalo Bills vs Los Angeles Chargers?▾

Buffalo Bills are favored over Los Angeles Chargers based on the latest moneyline (Buffalo Bills -370, Los Angeles Chargers +285).

What is the point spread for Buffalo Bills vs Los Angeles Chargers?▾

Buffalo Bills -7.00, Los Angeles Chargers 7.00. Spread reflects the projected margin between the two teams.

What is the over/under for Buffalo Bills vs Los Angeles Chargers?▾

The total (over/under) is 50.00. Over 50.00 or under 50.00 wins respectively.

When is Buffalo Bills vs Los Angeles Chargers?▾

Buffalo Bills vs Los Angeles Chargers is scheduled for Sep 27 at 01:00 PM ET.

More NFL picks

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    Mon, Sep 21
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    Sun, Sep 27
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    Sun, Sep 20
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    Sun, Sep 20
  • San Francisco 49ers vs Miami Dolphins
    Sun, Sep 20
  • Dallas Cowboys vs Washington Commanders
    Sun, Sep 20
See all NFL picks →
1

Expert Picks Available

Professional handicappers have analyzed this game

Betting Odds

Buffalo Bills logoBuffalo Bills
Los Angeles ChargersLos Angeles Chargers logo
Spread
-7.00
-115
7.00
-108
Moneyline
-370
FAV
+285
Total (O/U 50.00)
Over
-114
Under
-108
PicksToday logo

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Please gamble responsibly. If you have a gambling problem, please visit ncpgambling.org